ECPA Residues Workshop 2017




EuroMix efforts on international harmonisation on cumulative risk assessment were presented in a lecture by Angelo Moretto, form University of Milan, partner of EuroMix, at the  “ECPA Residues Workshop 2017, The current and future challenges”, held  in Brussels, 16-17 October 2017. The title of the presentation was ““Looking at harmonisation opportunities – the Euromix project and JMPR considerations” and it was well received by the about 80 attendants from different parts of the world and different sectors (food industry, pesticide producers, regulatory, farmers’ associations) and discussion continued after the session ended. There appears to be a lot of interest in any effort towards harmonization and consistency of approaches to risk assessment of pesticides.

News from EuroMix human cohort (WP 7)

Recruitment goals achieved!

We are happy to announce that the EuroMix human cohort (WP7) has reached the projected number of participants. In total 145 persons (99 women and 46 men, aged 23-70) were recruited among employees at the Norwegian Institute of Public Health (NIPH) and their family and friends, as well as students and employees at universities, hospitals and health institutions in the region of Oslo, Norway. Participation included self-monitoring of foods and cosmetic use for 24 hours, and in parallel the collection of 24 hours urine.  Skin wipes and blood samples were taken at the end of the 24-hour study period.

Dissemination activities in order to recruit volunteers

The EuroMix human cohort has been presented at internal meetings at NIPH and communicated through e-mails, the intranet (three headline-stories), and trough posters and stands during a research event on 16th of June 2017. Externally, two targeted Facebook campaigns were initiated (June + August), and several institutions were asked to shared information about the human cohort on their intranet.

Photo: NIPH employees visiting the EuroMix human cohort stand during a research event on 16th of June 2017

European Teratology Society Meeting

The 45th European Teratology Society Meeting was held in Budapest, Hungary on September 4-7, 2017. Elena Menegola and the team at the Univeristy of Milan were awarded during the meeting with „The Teddy Edward’s memorial Prize for Research into Congenital Malformation“ for their work in EuroMix work package 3 on the effects of teratogens on crania-facial morphogenesis.

The ETS (European Teratology Society) was created in 1971 and are dedicated to the prevention of adverse effects on reproduction and development. The core objectives of the European Teratology Society are to stimulate interest in, and promote the exchange of ideas and information about, the causes and prevention of adverse effects on reproduction and development allowing the exchange of knowledge among experts from academia, regulative agencies and industries.

The Teddy Edwards Prize for Research into Congenital Malformations is an  award to the poster or free communication, which best exemplifies the aims of the Society. It’s the main appreciation award assigned directly from the ETS committee.


Hazardous Substances Advisory Committee

Dr Marc Kennedy (Statistician at Fera) will give a talk on September 19th to Defra’s Hazardous Substances Advisory Committee (HSAC).

HSAC is considering the issue of combination effects of chemicals, working with others. The HSAC committee is aware that there are a number of ongoing initiatives being carried out in the international arena and has invited Dr Andy Hart and Dr Marc Kennedy to hear about Euromix. Dr Kennedy will give a general introduction to Euromix and some detail on the cumulative and aggregate exposure modelling. Dr Hart will give a second talk in December, in which the broader issues of uncertainty and risk will be covered. Other UK researchers will also present related research at these meetings.

The Hazardous Substances Advisory Committee (HSAC) provides expert advice on how to protect the environment, and human health via the environment, from potentially hazardous substances and articles, including nanomaterials.

WHO Chemical Risk Assessment Network

Jacob van Klaveren will present EuroMix at the 2nd meeting of the WHO chemical risk assessment network that will be hosted by the European food safety authority (EFSA) 20-22 June 2017 in Parma, Italy. This meeting is part of the ongoing WHO-EFSA network activities.

The agenda for the meeting can be found here.

For more information on the network, click here.




Fresenius MIXTOX Conference

2nd International Fresenius MIXTOX Conference “Toxicity of Chemical Mixtures: Risk, Hazard and Exposure Assessment”

8 Jun – 9 Jun 2017, Park Inn by Radisson Köln City West, Cologne/Germany

EuroMix participants are giving talks at this conference.

For more information click here.

EuroMix Workshop – International harmonisation

Second workshop on international harmonisation on the risk assessment of combined exposures to chemicals

Thon Hotel EU, Rue de la Loi 75, 1040 Bruxelles, Belgium

17 May 2017

The EUROMIX consortium organised the second of a series of workshops to discuss international harmonisation of approaches to the risk assessment of combined exposure to chemicals on 17th May 2017.  The workshop was held at the Thon Hotel EU, Brussels, Belgium.  The 19 participants at the workshop were drawn from a range of geographical and regulatory areas, with risk assessors and risk managers from several continents (Europe, USA, Canada and Brazil) and authorities (DG SANTE, DG ENV, EFSA, JRC, OECD, Codes Alimentarius, WHO, US EPA, US FDA, RIVM, BfR) present.

The main aims of this workshop were to understand current and upcoming legislative needs for cumulative risk assessment of chemicals (with a focus on the diet); how this varies across chemical sectors (e.g. pesticides, additives) and the extent to which this might be harmonized; how this varies across geographical region and the opportunities for harmonization; the role that scientific research, and particularly that of EuroMix, might play in the development and implementation of legislation in this area.

Risk managers in the areas of pesticides, food additives, chemical contaminants and chemicals in general provided perspectives on the need for cumulative risk assessment; practicalities of implementing risk management of combined exposures to chemicals within and across sectors; the degree of precaution necessary in current and future approaches; what do risk managers need from science? Participants in the EuroMix project outlined the approaches they proposed, including tiered assessment, the EuroMix toolbox, and the EuroMix approach to assessing chemical grouping using AOP-wise methods and uncertainty quantification.

Participants reached a number of general conclusions. Currently there is no overarching approach to cumulative risk assessment in Europe (or elsewhere) but work in now ongoing to explore this, for example at OECD and EFSA. Approaches to cumulative risk assessment vary across sectors and with geography. The most common approach for grouping chemicals is based on common structure and/or co-occurrence and/or designed function. EuroMix will explore the implications of different exposure and toxicology choices in grouping chemicals to enable harmonization where appropriate and desirable.

The conclusions of the workshop will be written up in the minutes of the meeting and will be explored further at the 3rd workshop in the series, to be held late 2017 or early 2018.

Participants at the Second EuroMix Workshop on the International Harmonisation of Approaches to the Risk Assessment of Combined Exposure to Chemicals, 17th May, 2017. Thon Hotel EU, Brussels, Belgium. Not shown are Alan Boobis, Peter Korytar, Jiri Sochor and Frans Verstraete.




First EuroMix Workshop on the International Harmonisation of Approaches to the Risk Assessment of Combined Exposure to Chemicals

The EuroMix consortium organised the first of a series of workshops to discuss international harmonisation of approaches to the risk assessment of combined exposure to chemicals over 20-21 October 2016. The workshop was held at the Hammersmith Campus of Imperial College London, the partner tasked with coordinating this activity within EuroMix. The 15 participants at the workshop encompassed wide geographical and regulatory coverage, with scientists from several continents (Europe, North America, South America, Asia, Australasia, Africa) and authorities (EFSA, OECD, JRC, US EPA, APVMA (Australia), FAO, RIVM, BfR) present.

The focused discussions covered a number of the key scientific issues that will need to be resolved to enable international harmonization of the approaches used. Aspects included the importance of explicit and transparent problem formulation, which categories of chemicals should be covered, what is meant by co-exposure, what factors (biological and/or exposure) should determine assessment groups, the role of detailed information on adverse outcome pathways/modes of action and how this might be obtained, whether there was a need to address the possibility of synergy, and probabilistic exposure assessment, including the need for common reporting formats.

Participants identified a number of areas where there was general agreement and those areas where further discussion would be necessary before harmonisation would be possible. The conclusions of the workshop will contribute to developing the agenda for the 2nd workshop in the series, to be held 17th May, 2017.


Participants at the First EuroMix Workshop on the International Harmonisation of Approaches to the Risk Assessment of Combined Exposure to Chemicals, 20-21 October, 2016. Hammersmith Campus, Imperial College London.

Here is the report of “EuroMix First Workshop on International Harmonisation on the Risk Assessment of Combined Exposures to Chemicals”.


EuroMix Stakeholder Workshop

Towards Harmonisation of Implementation of Test Strategies for Chemical Mixtures in Europe

The first EuroMix Stakeholders’ Workshop was held on 18 May 2017 at the Thon Hotel EU in Brussels, Belgium.

This workshop was organised to inform stakeholders on the progress made in the EuroMix project on the test strategy and the tools that will be released for future testing and risk assessment of mixtures. It also aimed to obtain feedback regarding the needs of stakeholders as well as which further steps can be taken to ensure project relevance to them.

In total, 72 participants attended the workshop, 50 stakeholders and 22 representatives from the beneficiaries. The participants came from the European Member States and the associated countries well as the USA, Canada Brazil and Japan.

The programme and presentations of the workshop can be found here.

A few photos from the event can be found here.



Stakeholder survey – opinion on tools and concepts

On a daily basis we are exposed to a mixture of multiple chemicals via food intake, inhalation and dermal contact. The risk to human health that may result from this, depends on how the effects of different chemicals in the mixture combine, and whether there is any synergism or antagonism between them. The number of different combinations of chemicals in mixtures is infinite and an efficient test strategy for mixtures is lacking. Furthermore, there is a societal need to reduce animal testing, which is the current practice in safety testing of chemicals.

The EuroMix project will deliver a mixture test strategy and test instruments using novel techniques. The tests will result in data needed for refining future risk assessment of mixtures relevant to different stakeholders. Ultimately, this will provide information for future risk management decisions on the safety of chemicals in mixtures to be taken by the European Commission and the Codex Alimentarius.

More information on the EuroMix concepts and tools can be found in this presentation.

Therefore, we would like to hear your opinion on the tools and concepts under investigation within EuroMixa and are inviting you to participate in our stakeholder survey.

Seventeen questions have been selected to evaluate our concepts and tools acceptance and understandability.

If you have attended one of the EuroMix training workshops or information sessions, please click here.

If you have NOT received any EuroMix training or taken part in information sessions, please click here.


5th consortium meeting

The 5th EuroMix consortium meeting was held April 4th – 6th, 2017 in Ljubljana, Slovenia. It consisted of work package (WP2-10) meetings, plenary consortium meetings and a general assembly meeting.

The main aims of the 5th consortium meeting were the following:

  1. To finalise test protocols for the animal study;
  2. To finalise the discussion on A, B (similar MoA) and A, C (dissimilar MoA) chemicals based on available in vitro test results;
  3. To set the next step in kinetic modelling;
  4. To discuss the concept (retain & refine, infrastructure, AOP-wise testing, modelling approaches, case studies in tier 1 and tier 2);
  5. To discuss and to prepare the first EuroMix stakeholder meeting.